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Arthus reaction : ウィキペディア英語版 | Arthus reaction
In immunology, the Arthus reaction (, ) is a type of local type III hypersensitivity reaction. Type III hypersensitivity reactions are immune complex-mediated, and involve the deposition of antigen/antibody complexes mainly in the vascular walls, serosa (pleura, pericardium, synovium), and glomeruli. This reaction is usually encountered in experimental settings following the injection of antigens. ==History== The Arthus reaction was discovered by Nicolas Maurice Arthus in 1903.〔Injections répétées de serum du cheval chez le lapin, ''Comptes rendus des séances de la Société de biologie et de ses filiales'', Paris, 55 (1903), 817–820.〕 Arthus repeatedly injected horse serum subcutaneously into rabbits. After four injections, he found that there was edema and that the serum was absorbed slowly. Further injections eventually led to gangrene.
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